Indications

BO-SE (selenium, vitamin E) is recommended for the prevention and treatment of white muscle disease (Selenium-Tocopherol Deficiency) syndrome in calves, lambs, and ewes. Clinical signs are: stiffness and lameness, diarrhea and unthriftiness, pulmonary distress and/or cardiac arrest. In sows and weanling pigs, as an aid in the prevention and treatment of diseases associated with Selenium-Tocopherol deficiency, such as hepatic necrosis, mulberry heart disease, and white muscle disease. Where known deficiencies of selenium and/or vitamin E exist, it is advisable, from the prevention and control standpoint, to inject the sow during the last week of pregnancy.

FOR VETERINARY USE ONLY

Diseases

• Selenium-Tocopherol Deficiency – White muscle disease

Administration

Inject subcutaneously or intramuscularly:
CALVES: 2.5-3.75 mL per 100 pounds of body weight depending on the severity of the condition and the geographical area.

Supplied

100 mL sterile, multiple dose vial

Storage

Store at 25°C (77°F) with excursions permitted between 23 – 32°C (74 – 89°F).

Warnings

Anaphylactoid reactions, some of which have been fatal, have been reported in animals administered BO-SE Injection. Signs include excitement, sweating, trembling, ataxia, respiratory distress, and cardiac dysfunction. Selenium-Vitamin E preparations can be toxic when improperly administered.

Residue Warnings

Discontinue use 30 days before the treated calves are slaughtered for human consumption. Discontinue use 14 days before the treated lambs, ewes, sows, and pigs are slaughtered for human consumption.

Precautions

Selenium-Tocopherol Deficiency (STD) syndrome produces a variety and complexity of symptoms often interfering with a proper diagnosis. Even in selenium deficient areas there are other disease conditions which produce similar clinical signs. It is imperative that all these conditions be carefully considered prior to treatment of STD syndrome. Serum selenium levels, elevated SGOT, and creatine levels may serve as aids in arriving at a diagnosis of STD, when associated with other indices. Selenium is toxic if administered in excess. A fixed dose schedule is therefore important (read package insert for each selenium-tocopherol product carefully before using).

IMPORTANT: Use only the selenium-tocopherol product recommended for each species. Each formulation is designed for the species indicated to produce the maximum efficacy and safety.

Adverse Reactions

Reactions, including acute respiratory distress, frothing from the nose and mouth, bloating, severe depression, abortions, and deaths have occurred in pregnant ewes. Do not use product with phase separation or turbidity.

Contact

U.S. only: Merck Animal Health contact us or call 1-800-211-3573.
For more information regarding efficacy and safety data, go to productdata.aphis.usda.gov
For additional information, please see the product label.