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August 24, 2020

Three-Year Duration of Immunity in Cats Following Vaccination against Feline Rhinotracheitis Virus, Feline Calicivirus, and Feline Panleukopenia Virus

Clinical Relevance Forty-two seronegative cats received an initial vaccination at 8 weeks of age and a booster vaccination at 12 weeks. All cats were kept in strict isolation for 3 years after the second vaccination and then were challenged with feline calicivirus (FCV) or sequentially challenged with feline rhinotracheitis virus (FRV) followed by feline panleukopenia […]

August 24, 2020

Efﬁcacy of an Inactivated FeLV Vaccine Compared to a Recombinant FeLV Vaccine in Minimum Age Cats Following Virulent FeLV Challenge

Abstract The aim of the study was to determine the efﬁcacy of an inactivated feline leukemia virus (FeLV) vac-cine (Versifel® FeLV, Zoetis.) compared to a recombinant FeLV vaccine (Purevax® FeLV, Merial Animal Health) in young cats, exposed under laboratory conditions to a highly virulent challenge model. The study was designed to be consistent with the general immunogenicity […]

August 24, 2020

Comparative Efficacy of Feline Leukemia Virus Inactivated Whole Virus Vaccine and Canarypox Virus-Vectored Vaccine by Modern Molecular Assays and Conventional Parameters

Purpose The purpose of this study was to compare the efficacy of two commercially available feline leukemia vaccines, Nobivac® Feline 2-FeLV (inactivated whole virus vaccine) and PureVax® Recombinant FeLV (live canarypox virus-vectored vaccine) following challenge with virulent feline leukemia virus. Read More about this study here

August 24, 2020

Feline Leukemia Virus Immunity Induced by Whole Inactivated Virus Vaccination

Abstract A fraction of cats exposed to feline leukemia virus (FeLV) effectively contain virus and resist persistent antigenemia/viremia. Using real-time PCR (qPCR) to quantitate circulating viral DNA levels, previously we detected persistent FeLV DNA in blood cells of non-antigenemic cats considered to have resisted FeLV challenge. In addition, previously we used RNA qPCR to quantitate […]

August 24, 2020

Feline Leukaemia Virus: a Review of Immunity and Vaccination

The availability of feline leukaemia virus {FeLV) vaccines has added a new and important dimension to the control of this infectious agent. FeLV vaccination is a controversial issue, however, partly because of differences in the formulation between the current products, partly because of conflicting claims by vaccine manufacturers and partly because experimental trials have shown […]

August 24, 2020

lmmunogenicity and Efficacy of a Commercial Feline Leukemia Virus Vaccine

Twenty young adult specific pathogen-free cats were randomly divided into two groups of 10 animals each. One group was vaccinated with two doses of feline leukemia virus vaccine according to the manufacturer’s recommendations. All 20 cats were challenge exposed oronasally (4 times over a I-week period), beginning 3 weeks after immunization, with a virulent subgroup […]

August 24, 2020

Comparitive Efficacy of Feline Leukemia Virus Inactivated Whole Virus Vaccine and Canarypox Virus-Vectored Vaccine by Molecular Assays and Conventional Parameters

August 24, 2020

Three-Year Duration of Immunity in Dogs Following Vaccination Against Canine Adenovirus Type-1, Canine Parvovirus, and Canine Distemper Virus

Clinical Relevance A challenge-of-immunity study was conducted to demonstrate immunity in dogs 3 years after their second vaccination with a new multivalent, modified-live vaccine containing canine adenovirus type-2, canine parvovirus (CPV), and ca-nine distemper virus (CDV). Twenty-three seronegative pups were vaccinated at 7 and 11 weeks of age. Eighteen seronegative pups, randomized into groups of […]

August 24, 2020

Diagnosing and Managing Canine Leptospirosis: IDEXX Reference Laboratories Introduces a RealPCR™ Test for Canine Leptospirosis

Leptospirosis, a zoonotic disease of worldwide significance, is caused by spirochetes of the genus Leptospira. Leptospirosis has been thought to most commonly affect young-adult, large-breed, outdoor dogs; however, small dogs in urban areas can also contract the disease. Pathogenic serovars infecting dogs include icterohaemorrhagiae, canicola, pomona, bratislava, grippotyphosa and autumnalis. Although serovar identification is of […]

August 24, 2020

Bacterin That Induces Anti-OspA and Anti-OspC Borreliacidal Antibodies Provides a High Level of Protection Against Canine Lyme Disease

Groups of 15 laboratory-bred beagles were vaccinated and boosted with either a placebo or adjuvanted bivalent bacterin comprised of a traditional Borrelia burgdorferi strain and a unique ospA- and ospB-negative B. burgdorferi strain that expressed high levels of OspC and then challenged with B. burgdorferi-infected Ixodes scapularis ticks. The vaccinated dogs produced high titers of […]