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Clinical Relevance A challenge-of-immunity study was conducted to demonstrate immunity in dogs 3 years after their second vaccination with a new multivalent, modified-live vaccine containing canine adenovirus type-2, canine parvovirus (CPV), and ca-nine distemper virus (CDV). Twenty-three seronegative pups were vaccinated at 7 and 11 weeks of age. Eighteen seronegative pups, randomized into groups of […]

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Leptospirosis, a zoonotic disease of worldwide significance, is caused by spirochetes of the genus Leptospira. Leptospirosis has been thought to most commonly affect young-adult, large-breed, outdoor dogs; however, small dogs in urban areas can also contract the disease. Pathogenic serovars infecting dogs include icterohaemorrhagiae, canicola, pomona, bratislava, grippotyphosa and autumnalis. Although serovar identification is of […]

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Groups of 15 laboratory-bred beagles were vaccinated and boosted with either a placebo or adjuvanted bivalent bacterin comprised of a traditional Borrelia burgdorferi strain and a unique ospA- and ospB-negative B. burgdorferi strain that expressed high levels of OspC and then challenged with B. burgdorferi-infected Ixodes scapularis ticks. The vaccinated dogs produced high titers of […]

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Laboratory-reared beagles were vaccinated with a placebo or a bacterin comprised of Borrelia burgdorferi S-1-10 and ospA-negative/ospB-negative B. burgdorferi 50772 and challenged after 1 year with B. burgdorferi­infectedlxodes scapu/aris ticks. For the placebo recipients, spirochetes were recovered from 9 (60%) skin biopsy specimens collected after 1 month, and the organisms persisted in the skin thereafter. […]

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Introduction Introduction of Lyme disease vaccines for use in canines has led to the widespread use of vaccine in Lyme disease-endemic areas of the United States. The SNAP 4Dx Plus Test Kit uses 8orrelia-specific peptide (C6 peptide) for detection of antibody to 8orrelia burgdorferi. Numerous published scientific articles have documented that those immunoassays incorporating the […]

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CIRDC refers to a contagious cough caused by one or more viral or bacterial pathogens. Laymen often refer to CIRDC as “kennel cough” because of its frequent association with dogs that have been recently housed in kennels or shelters. These settings allow for physical proximity of animals (which facilitates contagion spread) and contribute to disease […]

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Canine infectious respiratory disease complex (CIRDC) is a common disease complex caused by many different viruses and bacteria, including Bordetella bronchiseptica, Mycoplasma cynos, adenovirus type 2, distemper, influenza A virus, parainfluenza virus, pneumovirus and respiratory coronavirus. In March 2015, veterinarians in the Chicago area noted an increase in incidence of signs of canine infectious respiratory […]

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Clinical Relevance Healthy dogs with low antibody titer to Bordetella bronchiseptica were vacci-nated intranasally with an avirulent live vaccine, subcutaneously with an antigen extract vaccine, or subcutaneously and intranasally with a placebo. Intranasally vaccinated dogs developed B. bronchiseptica–specific IgA titers in nasal secre-tions that remained at high levels until the end of the study; dogs […]

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