1. SHEDDING: DEFENSE AGAINST URINARY SHEDDING CAUSED BY 4 KEY LEPTOSPIRA SEROVARS

PREVENT URINARY SHEDDING OF LEPTOSPIRES22

A key objective of vaccination is to prevent urinary shedding of leptospires, which has potential zoonotic risk:22,23

  • 0% of dogs vaccinated with Nobivac® Canine 1-DAPPv+L4 developed leptospiruria
  • All of the control dogs challenged with L. canicola and L. grippotyphosa, 80% of control dogs challenged with
    L. icterohaemorrhagiae, and 50% of control dogs challenged with L. pomona developed leptospiruria

 

Nobivac® Lepto4 is shown to be effective against leptospiruria associated with

  • L. grippotyphosa
  • L. canicola
  • L. icterohaemorrhagiae
  • L. pomona

LEPTOSPIREMIA

  • None of the dogs vaccinated with Nobivac ® Canine 1- DAPPv+L₄ developed leptospiremia
  • 100% of the control dogs challenged with L. canicola, L. grippotyphosa, L. icterohaemorrhagiae and 75% of the control dogs challenged with L. pomona showed leptospiremia, indicating the severe challenge model