Top tips for effective intranasal vaccination in dairy calves

As an intranasal vaccine, it delivers antigens directly to the calf’s nostrils. This method can initiate a rapid immune response with less interference from maternal antibodies acquired through colostrum ingestion. Other benefits of intranasal vaccines include being less stressful on the calf and less likely to induce systemic inflammation compared to injectable vaccines.²

6 steps for successful intranasal administration

Work closely with your veterinarian to establish a vaccination program that helps set your calves on a trajectory to join the dairy herd as healthy, productive cows. If you decide to implement intranasal vaccination, keep the following best practices in mind. Train your team to assess the overall health of calves first and consider using a technology tool like SenseHub^® Dairy Youngstock to quickly detect calves needing attention.

1) Properly store vaccines

Extreme temperatures, UV light, and improper handling and storage can reduce the vaccine’s effectiveness. Store and handle both the dehydrated vaccine and sterile diluent according to label directions. For best results, store vaccines in a well-functioning refrigerator used solely for storage of vaccines and equipped with an internal thermometer to monitor the temperature.

2) Carefully mix and handle vaccines

When reconstituting a modified live vaccine, only mix the quantity of bottles needed for immediate use and use the mixed vaccine within one hour. Insert one end of a clean transfer needle into the vaccine bottle and the other end into the sterile diluent. Squeeze enough diluent into the freeze-dried vaccine, swirling or gently rolling until the vaccine is completely dissolved — shaking too vigorously can damage the live organisms in the vaccine. Merge the reconstituted vaccine liquid into the bottle of diluent and apply the vaccine label to the bottle for proper identification.

Mixing procedures may vary depending on the brand and bottle size (number of doses), so double check the product label. Once mixed, use a cooler with ice packs to store vaccines at the proper temperature and out of sunlight. In cold weather, protect vaccines from freezing temperatures.

3) Restrain and position calf

Adequate calf restraint minimizes movement and optimizes efficacy. To restrain the calf’s head securely, wrap one arm around the neck and grasp the head firmly under the jaw. Tilt the head upward to about 45 degrees to effectively distribute the vaccine to nasal passages. Keep in mind, younger calves are typically easier to restrain and less resistant to having their head tilted into the proper position.

4) Effectively administer vaccine

Once calves are positioned and ready, gently insert the applicator with the cannula into the nostril. If using a longer cannula, only insert the tip about half an inch to reach the nasal mucosa without damaging the nasal lining. Depress the plunger to spray the vaccine — either one dose (2 mL) in one nostril or a half dose (1 mL) in each (check product label).

ALLFLEX^® CleanVax^™ nozzles feature an atomizer nozzle to reduce product drip and help ensure a hygienic and more even distribution of the vaccine inside the nostril.

5) Prevent cross-contamination between calves

When reloading syringes, always use clean and preferably new needles. Disinfect syringes and cannulas after use with boiling water. Do not sterilize syringes with chemical disinfectants and detergents since they can kill the modified live components. Using disposable shields over cannulas enhances hygiene and mitigates the risk of cross-contamination between calves.

6) Keep accurate vaccination records

Maintain detailed records of vaccinations and monitor calves for adverse reactions. If you decide to implement intranasal vaccination, keep the best practices below in mind. BOVILIS NASALGEN 3-PMH includes BluShadow^® that makes it easy to visually identify calves that have been vaccinated.

Reminders for effective immunization

For any vaccine to work properly and result in immunization, calves need to be in good health. Ensure calves receive high-quality colostrum, a comfortable environment, and proper hydration and nutrition. Follow up with your veterinarian to evaluate the effectiveness of the vaccination program and make any necessary adjustments based on the herd’s health status.

SenseHub^® Dairy Youngstock in not intended to diagnose, treat, cure or prevent any disease in animals. For the diagnosis, treatment, cure or prevention of disease in animals, you should consult your veterinarian. The accuracy of the data collected and presented through this product is not intended to match that of medical devices or scientific measurement devices.

References

1. Buczinski, et. al. Effects of calfhood respiratory disease on health and performance of dairy cattle: A systematic review and meta-analysis. J. Dairy Sci. July 2021. 104(7):8214-27. https://doi.org/10.3168/jds.2020-19941.
2. Engelken, T. J., Roth, J. A., Renter, D. G., Meyer, B. D., Burdett, W. W., Hill, K. L. The Effect of respiratory vaccine components and route of delivery on weight gain and inflammatory response in suckling beef calves. Bov. Pract. 2016. 50(2)165-74. https://doi.org/10.21423/bovine-vol50no2p165-174.